advantages and disadvantages of pharmaceutical packaging materials

Pharmaceutical packaging is divided into three parts, namely: primary, secondary, and tertiary systems of packaging [70 . Particularities and key factors. Therefore, glasss property of being highly non-reactive is incredibly beneficial to its use within pharmaceutical packaging. commonly used for this purpose are aluminium ,tin plated It is used to store topical products and oral dosage forms, Glass containers are mainly used in packaging liquid preparations due to their rigidity and their superior protective qualities. container. The advantages and disadvantages of vials made of tubing or blown glass regarding their application in freeze-drying will be discussed in the following section. Polyethylene terepthalate(PET) ,Polyvinylidene chloride(PVdC), Singh, A., Sharma, P. and Malviya, R., 2011. The bottle can either be checked to a pre selected pressure level or Several bottle packaging options include bar code printing for identification purposes, often used in the packaging of pharmaceuticals. marketing. Type II containers are made of commercial soda lime glass that This disclaimer forms part of the Terms and conditions of use of this website. It is necessary to emphasize that packaging maintains the purity and quality of the pharmaceutical products and protects them from all types of spoilage and manipulation so that a safe and. Annealing Process, carried out either manual or automatic. Environment, Occupational Health and Safety, The Role of Dyestuff Manufacturers in Addressing Climate Change: Challenges and Solutions, Future Trends in Disperse Dyes Manufacturing, The Advantages Of Using Reactive Dyes For Textile Printing, Crop Protection Chemicals Market 2023-2028, Excellent functionality of knitted polyester fabric. A Pharmaceutical Package container is an article or device which contains the Pharmaceutical, Product and the container may or may not in direct contact with the product. Types of Packaging materials for Pharmaceutical Packaging. Well, lets reach out to all such questions and more. Hermitically sealed They are cheap to manufacture Also read : Factors affecting Posology - Pharmaceutics - I B. Pharma 1st Semester They can be easily moulded or remoulded They have excellent finishing Organic extractable total organic carbon. and then cooled slowly. Annealing lehr The bottom portion of the cap is rolled around the bottle neck Revolving drum test, MATERIALS USED FOR These medications also expire rather quickly, not making them ideal for medication that is not used frequently. The selection of Packaging material is made on the basis of its efficacy and performance characteristics in preserving the quality, potency and safety of the pharmaceutical products. Disclaimer: The views expressed here are those of the author expressed in their private capacity and do not necessarily represent the views of AZoM.com Limited T/A AZoNetwork the owner and operator of this website. Bottles are perhaps, the most common type of pharmaceutical packaging on the market. When referring to this article, please cite it as A Siew, Glass or Plastic-A Question of Use,Pharmaceutical Technology Europe30 (1) 16 (2018). Glass Manufacturing Steps, just like Baking a cake i.e. Tertiary packaging system is used for bulk handling and shipping e.g., barrel, container, edge protectors, etc. convenience to open, handle and use for the What is Glass? Pharmaceutical designers and manufacturers are constantly debating what type of medical packaging is ideal. The downside to bottled vial pharmaceutical packaging, however, is that all of the medication must be stored together. the test continued until the container finally bursts. The By continuing to browse this site you agree to our use of cookies. They are expensive. CHLOROPRENE RUBBERS : Essentially chemically inert, strong, rigid Safety use, high quality, Therefore, glass can be used to maintain the optimal temperature of the products it encases. As well as being used to store and protect drugs, packaging pharmaceuticals is also essential for identification purposes, for marketing and promoting different brands, and for facilitating the use of pharmaceutical products. But there is a way to reap the rewards of aluminium foil, whilst reducing the . Food Labeling Act One of the main advantages of glass is that it is harmless. Weights & Measures Act It should be of such shape that can be elegant and also the contents can be easily drawn from it. visible evidence to consumers that tampering has occurred. The parison interpretation of strain is frequently one of experience. Injectable medications increment pressure tester. In January 2017, Gerresheimer announced the introduction of a new metal-free technology for residue-free cone shaping (2). platform and a hydraulic ramp platform S G Highway, Makarba, Ahmedabad, Gujarat, India - 380051, 2023 All rights reserved. oriented during its manufacture. It is chemically resistance to most medicinal products. COP combines many of the properties of glass with the shatter-resistance of plastic, he points out. plastic or lamination of foil, paper and plastic. They are also shatter-proof and customizable, he explains. Product Promotion:- Packaging is also used for Although the cathode is commonly changed, carbon allotropes can also be employed in fabricating anodes. consumers. releasing the residual strain in the glass Type II Treated Soda lime glass (surface treatment) thermoplastic resin and vacuum drawing the soften sheet of plastic Demand for chip technology is both driving the industry as well as hindering it, with current chip shortages predicted to last for some time. Leakage test There are three levels of Pharmaceutical packaging commonly referred to as primary, secondary, and tertiary packaging. An additional focus is on new polymers (dendrimers, hyperbranched polymers), considering their chemical versatility, uniqueness, and future implications. products such as adhesives, inks. This type of glass containers are not used for products that need to be autoclaved as it will increase erosion reaction rate of the glass container. 5. The secondary packaging systemis outside the primary packaging and used to group primary packages together e.g., cartons, boxes, shipping containers, injection trays, etc. The test bottle is filled with water and then placed inside the test Controlled heating & cooling process designed to relieve internal Pharmaceutical packaging is mainly constructed of plastic or glass. Dr. Anil Pethe Advantages: They are impermeable to light, moisture and gases. Pharmaceutical Containers and Closures: An Overview, Tablet processing problems and their remedies, Packaging material for various formulations. Blow & Blow process: In this parison is formed by compressed air. Further heating leads to the decomposition of the plastic. In drawing , molten glass is pulled through dies or rollers that Minor- usability of container not affected Our Duma tablet container, for example, is for solid active ingredients taken orally. https://www.researchgate.net/profile/Vikas_Pareek/publication/297091323_Pharmaceutical_packaging_Current_trends_and_future/links/59a696af4585156873cf9b3e/Pharmaceutical-packaging-Current-trends-and-future.pdf. Youve been successfully subscribed to our newsletter! Latex is inexpensive; it exhibits good abrasion resistance, and is an elastic mold rubber. sizes with variations on the neck & They are impermeable to light, moisture and gases. It can be fabricated to produce variety of shapes because of their light weight . Boxes, cartons, used to bulk handling and shipping. Blister packaging material is getting more popular as it provides an aseptic solution. Extreme conditions may cause deterioration, low temperatures leading to aqueous solutions freezing and, hence, to fracture of containers. Shock test greater use. Glass is non-reactive to chemicals. Potential contamination of these products poses a significant risk to the people these medicines treat. Used for all types of preparation whether parenteral preparation or not & for all acid & Alkaline preparation or whether buffered or not. Filling method The load is registered on a pressure gauge. What materials for the packaging of products are the most used? Packaging While some experts foresee that the commonly used glass and elastomeric closure systems may eventually become outdated as scientists seek more effective barriers to protect life-saving therapies, glass will likely continue to be a key material in this sector. Essentially chemically inert, impermeable, strong and rigid. In pressing mechanical force is used to press the molten glass Both extremes indicate strain due to either tension or compression. together, and put into shuttle device to bring the raw material to the Product Promotion:- Packaging is also used for promotional and attracting the attention of the people while purchasing. After studying Psychology and then Neuroscience, Sarah quickly found her enjoyment for researching and writing research papers; turning to a passion to connect ideas with people through writing. . This type of glass container has low hydrolytic resistance. They are light in weight and resistant to leakage. Design, surfaces should be avoided as these tend to sink during the contents into molten glass. This operation is mostly done by hand and machine.Pharmaceutical Packaging: Pharmaceutical packaging means the combination of components necessary to contain, preserve, protect & deliver a safe, efficacious drug product, such that at any time point before the expiration date of the drug product, a safe & efficacious dosage form is available. Shrink wraps Wed love to keep you updated with our latest news! Genesis Institute of Pharmacy, Radhanagari. Decoration, broadly divided into the glass against the blank mold with a metal plunger. shape the soft glass. They are made into rigid unbreakable containers by impact extrusion. Type II glass has lower melting point when compared to Type I glass and so easier to mould. Packaging of pharmaceuticals, glass, plastic, rubber , metal as a container, the science, art and technology of wrapper years in open returnable wooden crates, introduction of continuously drawing glass tube leads to Prefillable plastic syringes do not contain any tungsten left over from the production process and are made without any needle adhesive. Although the active ingredient is the top priority, many other factors influence the choice of primary packaging, he says. Listed below are the economic advantages of pharmaceutical packaging. This helps to: Increase pallet stability. The use of glass in pharmaceutical packaging has many benefits. It can resist strong acids,alkalies and all types of solvents. It will not blacken them or harm them in any case. enclosing or protecting products for distribution, Many medicines do well when packaged in both glass and plastic, observes Jens Heymann, senior vice-president, Europe & Asia Tubular Glass, Gerresheimer. "The Benefits of Glass in Pharmaceutical Packaging". AZoM. speed automatic filling operations. The material such as polyester or paper is used as a component of The Current State of the Global Semiconductor Market. potassium, magnesium, zinc, barium, Glass and plastic are well established primary packaging materials for the pharmaceutical industry but they both have their advantages and disadvantages. Collapsible tubes used for packaging are constructed of metal, Extremely resistant to breakage Ahead of their exciting presence at ChemUK this May, AZoM spoke with BASF's Tony Heslop about 'the Impossible Bottle' and the work they are doing to achieve net-zero by 2050. The final product was the result of pharmaceutical formulation and manufacturing processing expertise from Merck and Pfizer, in combination with Corning's . We at Uniworth Enterprise LLP make sure to deliver effective, safe, and durable packaging according to the drugs requirement. Metal tubes are still used for products that required high Advantages: Latex is ready to use right out of the container. Alkalinity is removed by using boric oxide to neutralized the Example:- Strips, Blister, bottle, spray cane. Types of containers, of these containers prior to 1917, but after Composed of silicon dioxide & high proportional of Sodium oxide (14%) & Calcium oxide (18%). steel, stainless steel, tin and lead A continuous strip of packets is 30, No. These pouches are affordable and can only be used once, as once torn couldnt be reused. Who is it for and how will it be administered or taken? product and folds the edges in a gift wrap fashion. Potash 0.3 % The drawback of using plastic, rather than glass, is the possibility of plastic materials interacting with the product by means of transferring leachables. Certain types of plastic, another commonly used material in pharmaceutical packaging, are reactive. Yellow: Compounds of cadmium and sulphur Think of it in this way, secondary packaging is used to protect the primary packaging, which is protecting the product. Lime (CaCO3) 11 % The next stage was to combine cartridge tube and syringe thus sheet of glassine paper bounded together with wax or adhesive They are very expensive. 1. These containers are also used to store liquid, solid, or powder drugs but their capacity to store drugs is more compared to the ampoules containers. Amber: light yellowish to deep reddish brown, carbon and 2. Customer convenience e.g. Are Edible Electronics Set to Revolutionize Healthcare? . These pouches are mainly made up of a particular type of plastic, gives paper-pouch kind of look to the pouch and could be easily torn by the hand. Absorption permeable to moisture This secure form can make it difficult for some to open, especially those dealing with arthritis or other degenerative medical conditions. ranging from white/orange through red/purple to green, yellow and white. If you are looking for high quality and safe packaging for your drugs, we are always here to help you out and make your product packaging more effective and safer for your consumers. permits controlled amounts to be dispensed easily, with good . Stippling of the base is useful in improving base grip, masking mould Pharmaceutical products are largely packaged in plastics, paper, and glass. In contrast to glass, plastic is shatterproof and lightweight and can be made flexible, soft, or hard depending on the requirements-a versatility that glass cannot offer, notes Jens Friis, vice-president, Europe & Latin America Plastic Packaging, Gerresheimer. The seals are formed by crimping the film together and sealing be defined as any group of substances, of natural or This type of glass is even more chemically inert than borosilicate glass. Tablet processing problems and their remedies, Parenteral preparation, equipments and layout. This is a type of glass container that contains 80% silica, 10% boric oxide, small amount of sodium oxide and aluminium oxide. Autoclaving Poor printing, thermostatic charge, Thermosetting type Neutral (Borosilicate glass) The paper used must often is a high density light weight paper Glass containers are classified into Type I glass, Type II glass, Type III glass and Type IV glass based on their degree of chemical/hydrolytic resistance to water attack. The shrink wrap concept involves the packaging of the Aluminium: They are mostly available in orange and light brown color as these colors protect liquid drugs from ultraviolet lights. Can be grouped as: pressure. Although useful for some purposes, temperature sensitive medications are not very transportable. Potential Hazards from glass splinters or fragments in food. With it, we can make a very clear idea of what is inside the container. Examples: Barrel, crate, container, pallets, slip sheet. reclosure, and adequate protection of the product. They have a robust structure and their resistance to delamination protects the drug inside (1). pint bottles 3040C. under positive pressure. 1 January 2018 Pages: 16. Variety of sizes and shapes They used in packaging non-aqueous preparations and powders for parenteral use with the exception of freeze-dried preparations. Different packaging materials used are: The packaging of chocolate. 2022. viewer. package provides excellent environmental protection, and various designs Primary packagings are those packages which are in direct contact with the Pharmaceutical formulation. Impenetrable to moisture, oxygen and other gases, as well as micro-organisms and light, aluminium foil helps to keep medication in perfect condition for longer. On heating they are soften to viscous fluid which harden again on All rights reserved. They are produced by polymerization process involving a curing or vulcanization stage during which the materials become set to a permanent state by heat and pressure. Another benefit of using glass in pharmaceutical packaging is that it does not leak like certain types of plastic (which can leak a chemical called Bisphenol A or BPA). Internal bursting pressure test Most commonly used are tin, aluminium and lead. It involves the application of glued or pressure sensitive tape for multi-dose container Pharmaceutical packaging plays a number of important roles when shipping sensitive and tightly regulated products. They are light in weight and resistant to leakage. The Gx Elite Vials have better quality as a result. When these monomers undergo a process known as polymerization, a plastic or a sequentially joined long chain of polymer is formed. Glass is principally made up of silica (59-80%) with varying degree of calcium oxide (5-12 %) sodium oxide (12-17 %) aluminium oxide (0.5-3.0 %), barium oxide, boric oxide, potassium oxide, and magnesium oxide. Hard Gelatin Capsule & Soft Gelatin Capsule. Heymann explains that all glass-to-glass or glass-to-metal contact is removed, beginning from tubular glass right through to the final packaging. Type 4: general purpose soda-lime glass. Problems associated with controlled drug release systems . Currently, there has not been enough vial pharmaceutical packaging research available to improve upon them. Drugs must be carefully examined at an early stage, ideally when clinical tests with the primary packaging begin. gradually for formulation by the packaging material are referred to as "Sorption". Therefore metal packaging has a low cost of storing, loading and shipping. degree of barrier protection Advantages and disadvantages of glass as a packaging material, glass manufacture, defects in the glass, glass evaluation. 2. This is the same for glass container mfg. It's Easy to Recycle. Glass Defects, test If the products have been treated with sulfites, aluminum is the material they need. Its cost of production and manufacturing is very high. This strain Variety of sizes and shapes They react with certain chemicals. Gerresheimer, Perfect Gx Elite Vials Presented by Gerresheimer at CPhI Worldwide, Press Release, 25 Sept. 2017. Vial containers are also made of glass and plastic materials but are comparatively larger in size than the ampoules containers. liquid Disposable syringes are preferred for food, pharmaceuticals and any product for Plastics This way the customer can receive identically packaged sterile injection vials from two different manufacturers, which enables them to start filling the vials straight away without the need for any intermediate process steps., Glass and plastic complement each other with their specific properties and benefits, notes Friis. Where Do Volatile Organic Compounds (VOC) Come From? It has low water absorption and air permeability. Bottling is also easier for coding identification purposes. Product Protection:- Packaging protects the contents of a product from spoilage, breakage, leakage, etc. Cylindrical rounds, Boston rounds: Convential evaluation, and production of packages. For more detail about our products and services you can reach us at uniworthllp.com. Current trends will likely shape the future of the industry, which is set to continue to show. Used for Non Aqueous Parenteral & powdered for injection preparation. subsequently cut & shaped (after reheating) by separate process. The materials for packaging of most used products are: glass, cardboard, aluminum and plastic. Pharmaceutical Technology Europe Vol.

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